Neuroligin (pan) (F1H7H) Rabbit Monoclonal Antibody #23928
- WB
- IP
- IF
Product Specifications
| REACTIVITY | M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 90-110 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
- IF-Immunofluorescence
Species Cross-Reactivity Key:
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
| Immunofluorescence (Frozen) | 1:50 - 1:200 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.
Species predicted to react based on 100% sequence homology:
Source / Purification
Background
Multiple neuroligin and neurexin isoforms are encoded in the human and mouse genomes. Alternative splicing further diversifies these families, generating numerous isoforms that differ in developmental expression, synaptic localization, and functional specificity. For example, neuroligin-1 is enriched at glutamatergic synapses, neuroligin-2 at GABAergic synapses, and neuroligin-3 at both (3). Interestingly, neuroligin-4 localizes to glutamatergic synapses in humans but to glycinergic synapses in mice, indicating species-specific functional divergence (4). Additionally, neuroligins are also expressed in glial cells, suggesting potential roles in non-neuronal signaling and synaptic support (5). Mutations or dysregulation of neuroligin genes have been genetically linked to several neurodevelopmental and neuropsychiatric disorders, including autism spectrum disorders, likely due to disruptions in synaptic structure and excitatory/inhibitory balance (3).
Alternate Names
6330415N05Rik; BB179718; Kiaa1070; MGC107366; mKIAA1070; neuroligin 1; Neuroligin-1; NL1; Nlg1; Nlgn1
Limited Uses
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