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CLEC2D (E4K1H) Rabbit Monoclonal Antibody #24276

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  • WB
  • IP

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 20-30
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    CLEC2D (E4K1H) Rabbit Monoclonal Antibody recognizes endogenous levels of total CLEC2D protein. Based on the antigen sequence, this antibody is predicted to recognize multiple isoforms of CLEC2D.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human CLEC2D protein.

    Background

    C-type lectin domain family 2 member D (CLEC2D), also known as lectin-like transcript 1 (LLT1) and osteoclast inhibitory lectin (OCIL), is a type II transmembrane C-type lectin receptor primarily expressed upon immune cell activation in T cells, B cells, NK cells, and plasmacytoid and monocyte-derived dendritic cells (1-4). CLEC2D interacts with NKR-P1A (KLRB1, CD161) on NK cells and some subsets of T cells, inhibiting NK cell cytotoxicity while alternatively inducing proliferation and IFNγ production in T cells (2-4). CLEC2D is also expressed by osteoblasts, inhibiting osteoclast formation and bone resorption (5,6). Multiple isoforms of CLEC2D produced by alternative splicing have been identified (7).

    Alternate Names

    C-type lectin domain family 2 member D; C-type lectin related f; C-type lectin superfamily 2, member D; CLAX; CLC2D; CLEC2D; lectin-like NK cell receptor; Lectin-like transcript 1; LLT-1; LLT1; OCIL; osteoclast inhibitory lectin

    For Research Use Only. Not for Use in Diagnostic Procedures.
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