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alpha/beta-Synuclein (Syn205) Mouse Monoclonal Antibody #2644

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    Product Specifications

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 18
    Source/Isotype Mouse IgG1
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    • IHC-Immunohistochemistry 
    • IF-Immunofluorescence 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50
    Immunohistochemistry (Paraffin) 1:100
    Immunofluorescence (Frozen) 1:200

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    For a carrier free (BSA and azide free) version of this product see product #79161.

    Protocol

    Specificity / Sensitivity

    alpha/beta-Synuclein (Syn205) Mouse Monoclonal Antibody detects endogenous levels of total synuclein protein. This antibody detects recombinant α and β-synuclein (Giasson, B.I. et al., 2000).

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with human recombinant α- and β-synucleins and the epitope maps to the carboxy terminus of the protein.

    Background

    α-Synuclein is a protein of 140-amino acids expressed abundantly in the brain. α-Synuclein is also the main component of pathogenic Lewy bodies and Lewy neurites. Research studies have shown that mutations of the α-Synuclein gene are linked to Parkinson's disease (1).

    Alternate Names

    Alpha-synuclein; alpha-synuclein, isoform NACP140; Beta-synuclein; I(2)-synuclein; I+/--synuclein; MGC110988; NACP; non A-beta component of AD amyloid; Non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; PARK1; PARK4; PD1; SNCA; SNCB; synuclein alpha; synuclein alpha-140; synuclein beta; synuclein, alpha (non A4 component of amyloid precursor); synuclein, beta; SYUA; SYUB; truncated alpha synuclein

    For Research Use Only. Not for Use in Diagnostic Procedures.
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