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MFSD1 (F2B4C) Rabbit Monoclonal Antibody #28569

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  • WB

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 35
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    MFSD1 (F2B4C) Rabbit Monoclonal Antibody recognizes endogenous levels of total MFSD1 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MFSD1 protein.

    Background

    Major facilitator superfamily domain-containing protein 1 (MFSD1) is a member of the solute carrier (SLC) superfamily that functions as a lysosomal dipeptide exporter (1-3). It forms a heterodimeric complex with glycosylated lysosomal membrane protein (GLMP) that functions as a critical accessory subunit for MFSD1 (3). MFSD1 knockout mice develop splenomegaly and severe liver disease, phenotypes that are mimicked in GLMP knockouts (4). In tumor models, loss of MFSD1 enables high levels of invasion and metastasis (5). MFSD1 is expressed in the TFEB gene network regulating lysosomal biogenesis and function (6).

    Alternate Names

    FLJ14153; major facilitator superfamily domain containing 1; Major facilitator superfamily domain-containing protein 1; MFSD1; Minerva; SMAP-4; SMAP4; Smooth muscle cell-associated protein 4

    For Research Use Only. Not for Use in Diagnostic Procedures.
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