LKB1 (D60C5) Rabbit Monoclonal Antibody #3047
- WB
Product Specifications
| REACTIVITY | H M R Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 54 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Simple Western™ | 1:10 - 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Mutation in the corresponding LKB1 gene causes Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder characterized by benign GI tract polyps and dark skin lesions of the mouth, hands, and feet (6). A variety of other LKB1 gene mutations have been associated with the formation of sporadic cancers in several tissues (7).
- Baas, A.F. et al. (2004) Trends Cell Biol 14, 312-9.
- Marignani, P.A. (2005) J Clin Pathol 58, 15-9.
- Lizcano, J.M. et al. (2004) EMBO J 23, 833-43.
- Hardie, D.G. (2004) J Cell Sci 117, 5479-87.
- Sapkota, G.P. et al. (2002) Biochem J 362, 481-90.
- Jenne, D.E. et al. (1998) Nat Genet 18, 38-43.
- Sanchez-Cespedes, M. (2007) Oncogene 26, 7825-32.
Alternate Names
hLKB1; Liver kinase B1; LKB1; PAR-4; PAR4; PJS; polarization-related protein LKB1; Renal carcinoma antigen NY-REN-19; serine/threonine kinase 11; Serine/threonine-protein kinase 11; Serine/threonine-protein kinase LKB1; Serine/threonine-protein kinase STK11; STK11
Limited Uses
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