Phospho-beta-Dystroglycan (Tyr892) (E6T9O) Rabbit Monoclonal Antibody #32248
- WB
- IP
Product Specifications
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 45 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:100 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Phosphorylation of β-dystroglycan at Tyr892 regulates protein-protein interaction and subcellular localization (3-5). β-dystroglycan interacts with nuclear envelope proteins emerin and lamin B1 to regulate nuclear architecture and function (6).
- Bozzi, M. et al. (2009) Matrix Biol 28, 179-87.
- Moore, C.J. and Winder, S.J. (2012) Neuromuscul Disord 22, 959-65.
- James, M. et al. (2000) J Cell Sci 113 (Pt 10), 1717-26.
- Sotgia, F. et al. (2003) Biochemistry 42, 7110-23.
- Gracida-Jiménez, V. et al. (2017) Sci Rep 7, 9906.
- Vélez-Aguilera, G. et al. (2018) Biochim Biophys Acta Mol Cell Res 1865, 406-420.
Alternate Names
156DAG; A3a; AGRNR; Alpha-DG; Alpha-dystroglycan; Beta-DG; Beta-dystroglycan; DAG; DAG1; Dystroglycan; Dystroglycan 1; dystroglycan 1 (dystrophin-associated glycoprotein 1); Dystrophin-associated glycoprotein 1; LGMDR16; MDDGA9; MDDGC7; MDDGC9
Limited Uses
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