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NLRC5 (D9Z5X) Rabbit Monoclonal Antibody #33343

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  • WB

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 205
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    NLRC5 (D9Z5X) Rabbit Monoclonal Antibody recognizes endogenous levels of total NLRC5 protein. This antibody recognizes isoforms 1-6 of NLRC5 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro131 of human NLRC5 protein.

    Background

    NLRC5 (NOD-like receptor family CARD domain containing 5, NOD4, CITA, NOD27) is a member of the NLR family of pattern recognition receptors (PRRs) involved in innate immunity (1,2). NLRC5 is predominantly expressed in hematopoietic cells, and is upregulated by IFN-γ (1-4). NLRC5 transcriptionally regulates the MHC class I antigen presentation pathway, and induces the expression of β2-microglobulin, TAP1, and LMP2 genes, in addition to MHC class I (3-5). In cancer, NLRC5 is critical for inducing cytotoxic CD8+ T cell activity and is a potential target for cancer immune evasion (6,7).

    Alternate Names

    Caterpiller protein 16.1; CLR16.1; FLJ21709; FLJ39711; NLR family CARD domain containing 5; NLR family, CARD domain containing 5; NLRC5; NOD-like receptor C5; NOD27; NOD4; Nucleotide-binding oligomerization domain protein 27; Nucleotide-binding oligomerization domain protein 4; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 5; nucleotide-binding oligomerization domains 27; Protein NLRC5

    For Research Use Only. Not for Use in Diagnostic Procedures.
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