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SLC25A39 (F1G2C) Rabbit Monoclonal Antibody #34281

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  • WB
  • IP

    Product Specifications

    REACTIVITY M
    SENSITIVITY Endogenous
    MW (kDa) 38
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • M-Mouse 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    SLC25A39 (F1G2C) Rabbit Monoclonal Antibody recognizes endogenous levels of total SL25A39 protein. This antibody detects 70 kDa, 80 kDa, and 100 kDa proteins of unknown identity in some cell lines.

    Species Reactivity:

    Mouse

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of mouse SLC25A39 protein.

    Background

    Members of the solute carrier family 25 (SLC25) transport molecules across the inner mitochondrial membrane (1,2). Mutations in these carriers often result in rare but severe pathologies (3). Solute carrier family 25 member 39 (SLC25A39) and its paralogue SLC25A40 were found to be essential for mitochondrial import of glutathione, thereby protecting against oxidative stress and mitochondrial dysfunction (4,5). Changes in SLC25A39 and SLC25A40 expression were found in cholestasis-associated renal injury and LPS-induced inflammation (6).

    Alternate Names

    3010027G13Rik; D11Ertd333; D11Ertd333e; MGC144572; MGC144573; Probable mitochondrial glutathione transporter SLC25A39; Q9D8K8; S2539; Slc25a39; Solute carrier family 25 member 39; solute carrier family 25, member 39

    For Research Use Only. Not for Use in Diagnostic Procedures.
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