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ENPP1 (E4I2P) Rabbit Monoclonal Antibody #40036

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  • WB

    Product Specifications

    REACTIVITY M R
    SENSITIVITY Endogenous
    MW (kDa) 110
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    ENPP1 (E4I2P) Rabbit Monoclonal Antibody recognizes endogenous levels of total ENPP1 protein.

    Species Reactivity:

    Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu281 of mouse ENPP1 protein.

    Background

    Ectonucleotide pyrophosphatase-phosphodiesterase 1 (ENPP1) is a single-pass, type II transmembrane protein primarily involved in ATP hydrolysis at the plasma membrane. Targeting of ENPP1 to the basolateral cell surface relies on the presence of a carboxy-terminal di-leucine-based signal (1). ENPP1 plays important roles in bone mineralization and soft tissue calcification (2-5). Mutations in the corresponding ENPP1 gene cause generalized arterial calcification in infancy (GACI) and idiopathic infantile arterial calcification (IIAC) (6,7). ENPP1 inhibits insulin receptor function and overexpression of this enzyme causes insulin resistance and glucose intolerance in mice (8,9). Genetic variants of ENPP1 have been associated with obesity and type 2 diabetes (10-12).

    Alternate Names

    1 ectonucleotide pyrophosphatase/phosphodiesterase 1; 4833416E15Rik; AI428932; Alkaline phosphodiesterase I; C76301; CD203c; E-N; E-NPP 1; E-NPP1; ectonucleotide pyrophosphatase/phosphodiesterase 1; Ectonucleotide pyrophosphatase/phosphodiesterase family member 1; Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form; Enpp1; Ly-4; Ly-41; Lymphocyte antigen 41; M6S1; NPP1; NPPase; Npps; Nucleotide diphosphatase; Nucleotide pyrophosphatase; OTTMUSP00000021307; PC-; PC-1; Pc1; Pca; Pca-1; Pdnp1; Phosphodiesterase I/nucleotide pyrophosphatase 1; Plasma-cell membrane glycoprotein PC-1; tiptoe walking; ttw; twy

    For Research Use Only. Not for Use in Diagnostic Procedures.
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