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APOBEC3B (E9A2G) Rabbit Monoclonal Antibody #41494

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  • WB

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 35
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    APOBEC3B (E9A2G) Rabbit Monoclonal Antibody recognizes endogenous levels of total APOBEC3B protein. This antibody weakly recognizes a 50 kDa band on unknown origen in cell lysates. Based on the sequence of the peptide antigen, this antibody is not expected to cross-react with other APOBEC3 family members.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro206 of human APOBEC3B protein.

    Background

    Members of the APOBEC3 subfamily of cytosine deaminases (APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H) function in innate immunity by preventing viral DNA replication, including that of HIV-1 (1-2). APOBEC3B mutation and aberrant expression in cancer is thought to result in mutation of genomic DNA, and to drive tumorigenesis. APOBEC3B is highly expressed in human breast cancer, glioma, and other human cancers (3-5).

    Alternate Names

    A3B; ABC3B; APOBEC1L; APOBEC3B; apolipoprotein B mRNA editing enzyme catalytic subunit 3B; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B; ARCD3; ARP4; bK150C2.2; cytidine deaminase; DJ742C19.2; DNA dC->dU-editing enzyme APOBEC-3B; FLJ21201; phorbolin 2; phorbolin 3; Phorbolin-1-related protein; Phorbolin-2/3; PHRBNL; Probable DNA dC->dU-editing enzyme APOBEC-3B

    For Research Use Only. Not for Use in Diagnostic Procedures.
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