Cell Signaling Technology Logo - Extra Large
Trial Size Available Flag
Recombinant Flag
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

LACTB (E2V3S) Rabbit Monoclonal Antibody #43817

Filter:
  • WB
  • IF

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 54
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IF-Immunofluorescence 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunofluorescence (Immunocytochemistry) 1:100 - 1:400

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    LACTB (E2V3S) Rabbit Monoclonal Antibody recognizes endogenous levels of total LACTB protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with recombinant protein specific to human LACTB protein.

    Background

    LACTB is a serine beta-lactamase-like protein that is most prominently expressed in skeletal muscle, heart and liver (1). It contains an amino-terminal transmembrane domain and is localized to the mitochondrial intermembrane space, where it is polymerized into stable filaments that promote intramitochondrial membrane organization and micro-compartmentalization (2). Studies in multiple breast cancer cell types have shown that LACTB can function as a tumor suppressor by promoting decreased levels of phosphatidylserine decarboxylase (PISD), leading to reduced cell proliferation (3). In accordance with this, levels of LACTB have been shown to be downregulated in hepatocellular carcinoma and colorectal cancer and associated with poor prognosis in both (4,5).

    Alternate Names

    FLJ14902; G24; lactamase beta; lactamase, beta; LACTB; mitochondrial 39S ribosomal protein L56; mitochondrial ribosomal protein L56; MRPL56; serine beta lactamase-like protein LACTB; Serine beta-lactamase-like protein LACTB, mitochondrial; serine beta-lactamase-like protein, mitochondrial

    For Research Use Only. Not for Use in Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    All other trademarks are the property of their respective owners. Visit our Trademark Information page.