Cell Signaling Technology Logo - Extra Large
Trial Size Available Flag
Recombinant Flag
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

Matrin 3 (F4Q5F) Rabbit Monoclonal Antibody #45457

Filter:
  • WB
  • IP
  • IF

    Product Specifications

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 125
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    • IF-Immunofluorescence 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Simple Western™ 1:10 - 1:50
    Immunoprecipitation 1:100
    Immunofluorescence (Frozen) 1:50 - 1:100
    Immunofluorescence (Immunocytochemistry) 1:400 - 1:1600

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Matrin 3 (F4Q5F) Rabbit Monoclonal Antibody recognizes endogenous levels of total matrin 3 protein.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human matrin 3 protein.

    Background

    Matrin 3 (MATR3) is a nuclear protein with two zinc finger domains, two RNA recognition motifs, and two intrinsically disordered regions. This protein is able to bind both DNA and RNA sequences and is a critical component of the nuclear matrix (1-4). MATR3 was initially implicated in human disease through its identification in a family with an autosomal dominant form of vocal cord and pharyngeal distal myopathy (5). Since then, exome sequencing has identified over a dozen point mutations in the MATR3 gene that have been linked to familial amyotrophic lateral sclerosis (ALS) and combined ALS/frontotemporal dementia (6-8). Moreover, abnormal MATR3 abundance, localization, and aggregation have been reported in motor neurons of patients with sporadic ALS (9,10).

    Alternate Names

    ALS21; DKFZp686K0542; DKFZp686K23100; KIAA0723; MATR3; matrin 3; Matrin-3; MGC9105; MPD2; VCPDM; vocal cord and pharyngeal weakness with distal myopathy

    For Research Use Only. Not for Use in Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    All other trademarks are the property of their respective owners. Visit our Trademark Information page.