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BHLHE40/DEC1 (E6T3E) Rabbit Monoclonal Antibody #45723

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  • WB
  • IP

    Product Specifications

    REACTIVITY H M
    SENSITIVITY Endogenous
    MW (kDa) 46
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:200

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    BHLHE40/DEC1 (E6T3E) Rabbit Monoclonal Antibody recognizes endogenous levels of total DEC1 protein.

    Species Reactivity:

    Human, Mouse

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human DEC1 protein.

    Background

    DEC1 (BHLHB2, BHLHE40) is a helix-loop-helix (bHLH) transcription factor that plays a role in the circadian system, or mammalian molecular clock (1-6). Its expression is elevated in response to various stimuli such as light pulses, growth factors, or hypoxia. DEC1 is involved in the homeostasis of regulatory T cells and the cellular differentiation, proliferation, and apoptosis of various cancers (4-6).

    Alternate Names

    basic helix-loop-helix domain containing, class B, 2; basic helix-loop-helix family member e40; basic helix-loop-helix family, member e40; BHE40; BHLHB2; BHLHE40; Class B basic helix-loop-helix protein 2; Class E basic helix-loop-helix protein 40; Clast5; DEC1; differentially expressed in chondrocytes 1; Differentially expressed in chondrocytes protein 1; differentiated embryo chondrocyte expressed gene 1; Enhancer-of-split and hairy-related protein 2; FLJ99214; HLHB2; SHARP-2; SHARP2; Stimulated by retinoic acid gene 13 protein; STRA13; Stra14

    For Research Use Only. Not for Use in Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    KARPAS cell line source: Dr. Abraham Karpas at the University of Cambridge.
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