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OGG1 (E4R5L) Rabbit Monoclonal Antibody

OGG1 (E4R5L) Rabbit Monoclonal Antibody #46271

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Product Specifications

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)	40
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

OGG1 (E4R5L) Rabbit Monoclonal Antibody recognizes endogenous levels of total OGG1 protein.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human OGG1 protein.

Background

8-oxoguanine DNA glycosylase (OGG1) is a DNA repair enzyme that repairs oxidative DNA damage. DNA bases like guanine can be oxidized to produce 7,8-dihydro-8-oxoguanine (8-oxoG), the most predominant form of oxidative DNA damage and a biomarker of oxidative stress. If left unrepaired, 8-oxoG can cause mutations during DNA replication. Through its DNA glycosylase and alpha-purine-DNA-glycosylase domains, OGG1 specifically removes 8-oxoG and its open-ring product 2,6-diamino-4-hydroxy-5-formamidopyrimidine from damaged double-stranded DNA (1). DNA damage is implicated in many human diseases, including inflammatory disorders, cancer, and neurodegenerative diseases such as Alzheimer’s disease (AD). OGG1 has recently been identified as a potential therapeutic target for AD by promoting DNA repair of oxidative DNA damage that accumulates in aging brain and AD mouse models (2,3). In addition to its role in DNA repair, OGG1 is implicated in various cellular regulatory functions, including transcriptional regulation, inflammation, cell death, and autophagy (4).

Alternate Names

8-hydroxyguanine DNA glycosylase; 8-oxoguanine DNA glycosylase; AP lyase; DNA-(apurinic or apyrimidinic site) lyase; DNA-apurinic or apyrimidinic site lyase; HMMH; HOGG1; MMH; MUTM; N-glycosylase/DNA lyase; OGG1; OGG1 type 1f; OGH1

Database Links

UniProt ID: O15527

Entrez-Gene Id: 4968

Limited Uses

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For Research Use Only. Not for Use in Diagnostic Procedures.

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