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Neurexin-3 (E7K3G) Rabbit Monoclonal Antibody

Neurexin-3 (E7K3G) Rabbit Monoclonal Antibody #48004

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Product Specifications

REACTIVITY	H M R
SENSITIVITY	Endogenous
MW (kDa)	180
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human
M-Mouse
R-Rat

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

Neurexin-3 (E7K3G) Rabbit Monoclonal Antibody recognizes endogenous levels of total Neurexin-3 protein.

Species Reactivity:

Human, Mouse, Rat

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala627 of human Neurexin-3 protein.

Background

Neurexins are a highly polymorphic cell surface protein family, containing single transmembrane regions and extracellular domains with repeated sequences similar to laminin A, slit, and agrin, proteins that are implicated in axon guidance and synaptogenesis (1,2). The family includes Neurexin-1, -2, and -3 (NRXN1, NRXN2, and NRXN3). Each member of the Neurexin family undergoes alternative splicing, resulting in α- and β-forms of Neurexin. α-neurexins contain six laminin/neurexin/sex (LNS)-hormone-binding globulin domains. β-neurexins are transcribed from an internal promoter of their respective genes. They are composed of an N-terminal β-neurexin-specific sequence that splices into the α-neurexin sequence LNS6 domain N-terminal, generating what is effectively an N-terminally truncated α-neurexin with a short N-terminal β-neurexin motif. γ-neurexins are only transcribed from the NRXN1 gene and splice into the NRXN1α and NRXN1β sequence of what encodes the LNS6 domain C-terminal (3).

Alternate Names

C14orf60; KIAA0743; MGC176711; neurexin 3; neurexin III; Neurexin III-alpha; neurexin III-beta; Neurexin-3; Neurexin-3-alpha; neurexin-3-beta; NRX3A; NRXN3

Database Links

UniProt ID: Q9Y4C0

Entrez-Gene Id: 9369

Limited Uses

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