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  3. FTSJ3 (E6T9J) Rabbit Monoclonal Antibody
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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

FTSJ3 (E6T9J) Rabbit Monoclonal Antibody #50607

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  • WB

    Product Specifications

    REACTIVITY H M
    SENSITIVITY Endogenous
    MW (kDa) 120
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    FTSJ3 (E6T9J) Rabbit Monoclonal Antibody recognizes endogenous levels of total FTSJ3 protein.

    Species Reactivity:

    Human, Mouse

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ile651 of human FTSJ3 protein.

    Background

    FTSJ3 is an RNA 2’-O-methyltransferase originally discovered through its role in processing of 34S pre-rRNA (1). In addition to contributing to RNA stabilization, 2’-O-methylation at the 5’-cap enables the innate immune system to distinguish self from non-self mRNA (2). While some viruses encode their own 2’-O-methyltransferase enabling them to avoid detection by the innate immune system, HIV does not (3,4). However, it was recently demonstrated that FTSJ3 is recruited to HIV RNA resulting in 2’-O-methylation of the HIV RNA genome and evasion of immune detection (5). Cells deficient in FTSJ3 produced virus with less 2’-O-methylation and upregulated type I interferon expression leading to reduced HIV expression and replication (5).

    Alternate Names

    2'-O-ribose RNA methyltransferase SPB1 homolog; EPCS3; FLJ20062; FtsJ homolog 3; FtsJ homolog 3 (E. coli); FtsJ RNA 2'-O-methyltransferase 3; FtsJ RNA methyltransferase homolog 3; FTSJ3; pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3; pre-rRNA processing protein FTSJ3; Protein ftsJ homolog 3; Putative rRNA methyltransferase 3; RRMJ3; rRNA (uridine-2'-O-)-methyltransferase 3; SPB1; SPB1 RNA methyltransferase homolog

    Database Links

    UniProt ID: Q8IY81


    Entrez-Gene Id: 117246


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    For Research Use Only. Not for Use in Diagnostic Procedures.
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