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IL-33 (F7H4J) Rabbit Monoclonal Antibody #52170

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  • WB

    Product Specifications

    REACTIVITY M R
    SENSITIVITY Endogenous
    MW (kDa) 18, 25-30
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    IL-33 (F7H4J) Rabbit Monoclonal Antibody recognizes endogenous levels of total IL-33 protein.

    Species Reactivity:

    Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln205 of mouse IL-33 protein.

    Background

    IL-33 (Interleukin-33, NF-HEV) is a nuclear cytokine that is part of the IL-1 family (1,2). Originally discovered as the ‘nuclear factor from high endothelial venules,’ it is widely expressed by endothelial cells as well as epithelial barrier tissues (1,5). IL-33 is involved in regulating type 2-associated innate immune responses (2,4). It is the ligand for ST2 which, along with IL-1RAcP, forms the IL-33R signaling complex (2,3). IL-33 functions as an alarmin upon cellular damage or stress, and is associated with allergic inflammation and asthma (5,6).

    Alternate Names

    9230117N10Rik; Il-; IL-33; Il1f; Il1f11; Il33; interleukin 33; Interleukin-33; Interleukin-33(102-266); Interleukin-33(109-266); NF-H; NF-HEV; nuclear factor from high endothelial venules

    For Research Use Only. Not for Use in Diagnostic Procedures.
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