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  3. TRIM2 (F1S4A) Rabbit Monoclonal Antibody
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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

TRIM2 (F1S4A) Rabbit Monoclonal Antibody #52291

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  • WB
  • IP

    Product Specifications

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 82, 72
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    TRIM2 (F1S4A) Rabbit Monoclonal Antibody recognizes endogenous levels of total TRIM2 protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro454 of human TRIM2 protein.

    Background

    Tripartite motif-containing (TRIM) proteins constitute a distinct family, many of which function as ubiquitin E3 ligases that mediate the degradation of normal regulatory proteins. Emerging evidence suggests that TRIMs can also promote the degradation of aberrant proteins, a property attributable to small ubiquitin-like (UBL) modifier (SUMO) E3 ligase activity (1). TRIM2 is a member of TRIM class VII, a class defined by the presence of a C-terminal NHL domain (2). It is predominantly expressed in the brain, where it is present in the cytoplasm and in cytoplasmic filaments, and has been reported to enhance axon specification during neuronal polarization (3). More recently, TRIM2 has also been implicated in regulating intracellular lipid levels, protecting cells from glutamine deprivation-induced apoptosis, and playing an antiviral role by limiting New World arenavirus entry into cells (4,5).

    Alternate Names

    CMT2R; E3 ubiquitin-protein ligase TRIM2; KIAA0517; RING finger protein 86; RING-type E3 ubiquitin transferase TRIM2; RNF86; TRIM2; tripartite motif containing 2; tripartite motif protein 2; tripartite motif protein TRIM2; tripartite motif-containing 2; Tripartite motif-containing protein 2

    Database Links

    UniProt ID: Q9C040


    Entrez-Gene Id: 23321


    Limited Uses

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    For Research Use Only. Not for Use in Diagnostic Procedures.
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