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PathScan® RP Ras Sandwich ELISA Kit #54004

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    Product Specifications

    REACTIVITY H Mk
    Application Key:
    • ELISA+-ELISA and/or ELISA-like Assays 
    Species Cross-Reactivity Key:
    • H-Human 
    • Mk-Monkey 

    Product Information

    Product Description

    The rapid protocol (RP) PathScan® RP Ras Sandwich ELISA Kit is a solid phase sandwich enzyme-linked immunosorbent assay (ELISA) that detects endogenous levels of Ras protein in a reduced assay time of 1.5 hours. Incubation of cell lysates and detection antibody on the coated microwell plate forms a sandwich with Ras in a single step. The plate is then extensively washed and TMB reagent is added for signal development. The magnitude of absorbance for the developed color is proportional to the quantity of Ras protein. Learn more about your ELISA kit options here.

    *Antibodies in this kit are custom formulations specific to kit.

    Protocol

    Specificity / Sensitivity

    The PathScan® RP Ras Sandwich ELISA Kit detects endogenous levels of Ras protein. The kit sensitivity is shown in Figure 1. This kit detects proteins from the indicated species, as determined through in-house testing, but may also detect homologous proteins from other species. This kit detects K-Ras, H-Ras, and N-Ras proteins as shown in Figure 2.

    Species Reactivity:

    Human, Monkey

    Background

    The 21 kDa guanine-nucleotide binding proteins (K-Ras, H-Ras, and N-Ras) cycle between active (GTP-bound) and inactive (GDP-bound) forms (1). Receptor tyrosine kinases and G protein-coupled receptors activate Ras, which then stimulates the Raf-MEK-MAPK pathway (2-4). GTPase-activating proteins (GAPs) normally facilitate the inactivation of Ras. However, research studies have shown that in 30% of human tumors, point mutations in Ras prevent the GAP-mediated inhibition of this pathway (5). The most common oncogenic Ras mutation found in tumors is Gly12 to Asp12 (G12D), which prevents Ras inactivation, possibly by increasing the overall rigidity of the protein (5,6).

    Alternate Names

    'C-K-RAS; ALPS4; C-BAS/HAS; c-H-ras; C-HA-RAS1; c-has/bas p21 protein; c-K-ras; c-Ki-ras; c-Ki-ras2; c-Kirsten-ras protein; c-ras-Ki-2 activated oncogene; cellular c-Ki-ras2 proto-oncogene; cellular transforming proto-oncogene; CFC2; CMNS; CTLO; GTP- and GDP-binding peptide B; GTPase HRas; GTPase HRas, N-terminally processed; GTPase KRas; GTPase KRas, N-terminally processed; GTPase NRas; H-Ras; H-Ras-1; H-RASIDX; Ha-Ras; Ha-Ras1 proto-oncoprotein; HAMSV; Harvey rat sarcoma viral oncogene homolog; Harvey rat sarcoma viral oncoprotein; HRAS; HRas proto-oncogene, GTPase; HRAS1; K-Ras; K-RAS; K-Ras 2; K-ras p21 protein; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; Ki-Ras; Kirsten rat sarcoma viral oncogene homolog; Kirsten rat sarcoma viral proto-oncogene; Kirsten rat sarcoma-2 viral (v-Ki-ras2) oncogene homolog; KRAS; KRAS proto-oncogene, GTPase; KRAS1; KRAS2; N-ras; N-RAS; N-ras protein part 4; NCMS; neuroblastoma RAS viral (v-ras) oncogene homolog; neuroblastoma RAS viral oncogene homolog; NRAS; NRAS proto-oncogene, GTPase; NRAS1; NS; NS3; NS6; OES; oncogene KRAS2; p19 H-RasIDX protein; p21ras; PR310 c-K-ras oncogene; RALD; Ras family small GTP binding protein H-Ras; RASH; RASH1; RASK; RASK2; RASN; transformation gene: oncogene HAMSV; Transforming protein N-Ras; transforming protein p21; Transforming protein p21; v-Ha-ras Harvey rat sarcoma viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; v-ras neuroblastoma RAS viral oncogene homolog

    For Research Use Only. Not for Use in Diagnostic Procedures.
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