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Synaptoporin (F7G6I) Rabbit Monoclonal Antibody #54017

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  • WB

    Product Specifications

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 35
    Source/Isotype Rabbit IgG1
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Synaptoporin (F7G6I) Rabbit mAb recognizes endogenous levels of total synaptoporin protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of mouse synaptoporin protein.

    Background

    Synaptoporin, also known as synaptophysin II, has been identified as an isoform of synaptophysin in small synaptic vesicles; it shares 58% homology with synaptophysin (1,2). Synaptoporin and synaptophysin are N-glycosylated membrane proteins that are part of a heteromultimeric complex in synaptic vesicle membranes (2). In general, synaptophysin is more widely distributed in most areas of the nervous system, whereas synaptoporin expression is restricted in some subareas, e.g., forebrain and spinal cord (2-4). After peripheral nerve injury, synaptoporin expression is upregulated in small dorsal root ganglion neurons and appears to play a role in both physiological and neuropathic pain states (5).

    Alternate Names

    1500003F20Rik; SPO; Synaptoporin; synaptorin; Synpr

    For Research Use Only. Not for Use in Diagnostic Procedures.
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