Plakophilin 2 (8H6) Mouse Monoclonal Antibody #55133
- WB
- IF
Product Specifications
| REACTIVITY | H Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 97 |
| Source/Isotype | Mouse IgG1 kappa |
Application Key:
- WB-Western Blotting
- IF-Immunofluorescence
Species Cross-Reactivity Key:
- H-Human
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Simple Western™ | 1:10 - 1:50 |
| Immunofluorescence (Immunocytochemistry) | 1:200 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
PKP2 is highly expressed in cardiac intercalated discs, where it is critical for maintaining the mechanical integrity of the myocardium (1,3). PKP2 mutations are associated with arrhythmogenic cardiomyopathy (ACM), a hereditary disorder characterized by defective desmosomes, which cause myocardium to be replaced with fibrofatty tissue, leading to arrhythmias and increased risk of sudden cardiac death (3).
PKP2 plays a context-dependent role in cancer and may influence tumor progression by modulating cell–cell adhesion and signaling pathways, such as Wnt/β-Catenin and epidermal growth factor receptor (EGFR) (4,5). Studies have demonstrated PKP2 overexpression in lung adenocarcinoma and gastric cancer, whereas PKP2 downregulation in colorectal cancer has been associated with poor prognosis and metastasis (4-6).
- Bass-Zubek, A.E. et al. (2009) Curr Opin Cell Biol 21, 708-16.
- Sobolik-Delmaire, T. et al. (2010) J Invest Dermatol 130, 2638-46.
- Popa, E. and Hostiuc, S. (2025) Biomolecules 15, 1512. doi: 10.3390/biom15111512.
- Dai, M. et al. (2024) J Gene Med 26, e3592.
- Hao, X.L. et al. (2019) Pathol Res Pract 215, 152438.
- Liu, Y. et al. (2024) Mol Carcinog 63, 1654-1668.
Alternate Names
ARVD9; MGC177501; PKP2; plakophilin 2; Plakophilin-2
Limited Uses
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