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GPR75 (F3P5Y) Rabbit Monoclonal Antibody

GPR75 (F3P5Y) Rabbit Monoclonal Antibody #56678

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Product Specifications

REACTIVITY	H M R
SENSITIVITY	Endogenous
MW (kDa)	75
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human
M-Mouse
R-Rat

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

GPR75 (F3P5Y) Rabbit Monoclonal Antibody recognizes endogenous levels of total GPR75 protein. This antibody detects a 50 kDa protein of unknown identity in some tissues.

Species Reactivity:

Human, Mouse, Rat

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala430 of human GPR75 protein.

Background

GPR75 is a G protein-coupled receptor. Protein-truncating GPR75 variants were associated with leanness and protection against obesity in humans. In addition, studies show that Gpr75 knockout (KO) mice fed with a high-fat diet are resistant to weight gain and have improved glycemic control and insulin sensitivity compared with wild-type (WT) mice (1). Furthermore, studies show that, in mice, Gpr75 mRNA expression is the most abundant in the brain. Gpr75 is widely expressed in the mouse brain, and a subset of Gpr75 is co-expressed with appetite-regulating hypothalamic neurons. Gpr75 KO mice are protected against liver lipid accumulation induced by a high-fat diet compared with WT mice (2). Moreover, studies on Gpr75 KO mice suggest a role of Gpr75 in the development of hypoxia-induced pulmonary hypertension (3).

Alternate Names

G protein-coupled receptor 75; GPR75; GPRchr2; MGC132002; Probable G-protein coupled receptor 75; WI31133

Database Links

UniProt ID: O95800

Entrez-Gene Id: 10936

Limited Uses

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For Research Use Only. Not for Use in Diagnostic Procedures.

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