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VMS1 (D10E6) Rabbit Monoclonal Antibody #5937

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  • WB

    Product Specifications

    REACTIVITY M
    SENSITIVITY Endogenous
    MW (kDa) 100
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • M-Mouse 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    VMS1 (D10E6) Rabbit Monoclonal Antibody detects endogenous levels of total VMS1 protein.

    Species Reactivity:

    Mouse

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly332 of mouse VMS1 protein.

    Background

    Mitochondria are membrane-bound subcellular organelles critical to many functions in eukaryotic cells (1). Several mechanisms have been found to play a role in mitochondria quality control (2). A recent study identified mitochondria-associated protein degradation as one such mechanism (1,2). The study showed that VMS1 (VCP/Cdc48-associated mitochondrial stress-responsive) interacts with VCP/Cdc48 and Npl4, two components in the endoplasmic reticulum-associated protein degradation pathway, and mediates the degradation of damaged mitochondrial proteins under stress conditions (1). Defective VMS1 compromises mitochondrial functions and cell viability (1).

    Alternate Names

    1300008P06Rik; 2810025E10Rik; ankyrin repeat and zinc finger domain containing 1; ankyrin repeat and zinc finger domain containing protein; Ankyrin repeat and zinc finger domain-containing protein 1; ANKZ1; Ankzf1; D1Ertd161; D1Ertd161e; tRNA endonuclease ANKZF1; VMS1

    For Research Use Only. Not for Use in Diagnostic Procedures.
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