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  3. ITM2A Antibody

ITM2A Antibody #62141

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  • WB

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 12, 39
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    ITM2A Antibody recognizes endogenous levels of total ITM2A protein.

    Species Reactivity:

    Human

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro9 of human ITM2A protein. Antibodies are purified by peptide affinity chromatography.

    Background

    Integral membrane protein 2A (ITM2A) is a type II membrane protein. ITM2A belongs to a family of membrane proteins defined by a conserved BRICHOS domain, a stretch of approximately 100 amino acids that may function as chaperone proteins (1). ITM2A, like other BRICHOS domain-containing proteins, may undergo proteolytic cleavage as it matures (2,3). BRICHOS domain-containing proteins exhibit anti-amyloidogenic activity, suggesting that these proteins may modulate formation of amyloid fibrils and oligomers (4). Aberrant amyloid formation is associated with amyloid diseases like Alzheimer’s disease. The specific function of ITM2A is unclear but it may play a redundant role in the development and function of T cells (5).

    Alternate Names

    BRICD2A; BRICHOS domain containing 2A; E25A; Integral membrane protein 2A; ITM2A; Protein E25

    Database Links

    UniProt ID: O43736


    Entrez-Gene Id: 9452


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    For Research Use Only. Not for Use in Diagnostic Procedures.
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