Rad51 Matched Antibody Pair #62341
- ELISA+
Product Specifications
| REACTIVITY | H M R Mk |
Application Key:
- ELISA+-ELISA and/or ELISA-like Assays
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
Product Information
Product Usage Information
Formulation
Storage
Product Description
The Rad51 Matched Antibody Pair is ideal for use with immunoassay technologies and high-throughput ELISA platforms requiring antibody pairs with specialized or custom antibody labeling. Labels include fluorophores, lanthanides, biotin, and beads. Platforms requiring conjugated Matched Antibody Pairs include MSD, Quanterix Simoa, Alpha Technology (AlphaScreen, AlphaLISA, LANCE, HTRF), and Luminex.
Learn how Matched Antibody Pairs move your projects forward, faster at cst-science.com/matched-antibody-pairs.
Background
DSBs that arise during S or G2 phase are repaired via homologous recombination, using the replicated sister chromatid as a repair template. Rad51 recombinase, a eukaryotic homolog of E. coli RecA, polymerizes and forms a filament along single-stranded DNA, mediating HR with the help of auxiliary proteins, including Rad54 and BRCA2 (reviewed in 2,3). BRCA2 binds Rad51 and targets it to single-stranded DNA, allowing it to displace replication protein A (RPA) (4). Five Rad51 paralogs exist in vertebrates (XRCC2, XRCC3, Rad51B, Rad51C, and Rad51D), and they all appear to be required for efficient HR (5).
Researchers have found that mutations in the Rad51 gene may be related to breast cancer risk (6). Some studies have implicated Rad51 as a potential marker for pancreatic cancer (7).
- Hartlerode, A.J. and Scully, R. (2009) Biochem J 423, 157-68.
- Sung, P. et al. (2003) J Biol Chem 278, 42729-32.
- Mazin, A.V. et al. (2010) DNA Repair (Amst) 9, 286-302.
- Jensen, R.B. et al. (2010) Nature 467, 678-83.
- Takata, M. et al. (2001) Mol Cell Biol 21, 2858-66.
- Antoniou, A.C. et al. (2007) Am J Hum Genet 81, 1186-200.
- Nagathihalli, N.S. and Nagaraju, G. (2011) Biochim Biophys Acta 1816, 209-18.
Alternate Names
BRCA1/BRCA2-containing complex, subunit 5; BRCC5; DNA repair protein RAD51 homolog 1; FANCR; hRAD51; HsRAD51; HsT16930; MRMV2; RAD51; RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae); RAD51 homolog A; RAD51 homolog protein; RAD51 recombinase; RAD51A; RECA; RecA-like protein; RecA, E. coli, homolog of; recombination protein A
Limited Uses
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