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SPTA1 (E3B3L) Rabbit Monoclonal Antibody #65118

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  • WB
  • F

    Product Specifications

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 60-100, 140, 160, 260, 280
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • F-Flow Cytometry 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Flow Cytometry (Fixed/Permeabilized) 1:200 - 1:800

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    SPTA1 (E3B3L) Rabbit Monoclonal Antibody recognizes endogenous levels of total SPTA1 protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln427 of human SPTA1 protein.

    Background

    Spectrin alpha chain, erythrocytic 1 (SPTA1), also known as erythroid alpha-spectrin, is a component of the erythrocyte plasma membrane skeleton along with beta-spectrin and protein 4.1. SPTA1 constitutes the lateral linkage in the membrane complex (1). Defects and dysfunction of SPTA1 can contribute to hereditary elliptocytosis (HE), hereditary poikilocytosis (HP), and hereditary spherocytosis (HS), which result in defects in red blood cell morphology and function (1,2).

    Alternate Names

    alpha-I spectrin; EL2; elliptocytosis 2; Erythroid alpha-spectrin; HPP; HS3; Spectrin alpha chain, erythrocyte; Spectrin alpha chain, erythrocytic 1; spectrin alpha, erythrocytic 1; spectrin, alpha, erythrocytic 1; spectrin, alpha, erythrocytic 1 (elliptocytosis 2); SPH3; SPTA; SPTA1

    For Research Use Only. Not for Use in Diagnostic Procedures.
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