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CUTL1 Antibody #81557

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  • WB
  • IP

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 200
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:200

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    CUTL1 Antibody recognizes endogenous levels of total CUTL1 protein. This antibody recognizes the p200 isoform (the full-length) and is not expected to recognize the p110 and p75 isoforms.

    Species Reactivity:

    Human

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln639 of human CUTL1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    CUTL1 (Cut-like 1), also known as CUX1 (Cut homeobox 1) (CUX1), is a transcription factor that has been implicated in many cellular processes in different tissues, such as cell migration, neuronal differentiation, and DNA repair (1-5). CUTL1 expression and activities are altered in cancer. Research studies have shown the CUTL1 gene to be a frequent target of loss-of-heterozygocity in various cancers (6,7). On the other hand, CUTL1 expression is elevated in many cancers and is associated with shorter disease-free survival (8). These accumulating evidence suggest that decreased CUTL1 expression promote tumor initiation and increased CUTL1 expression facilitates tumor progression (9). While full-length CUTL1 is about 200 kDa (p200), short forms p110 and p75 can also be generated by proteolytic processing and alternative transcription initiation site, respectively (10, 11).

    Alternate Names

    CASP; CCAAT displacement protein; CDP; CDP/Cut; CDP1; Clox; COY1; cut homeobox; cut homolog; cut like homeobox 1; cut-like 1, CCAAT displacement protein; cut-like homeobox 1; CUTL1; CUX; Cux/CDP; CUX1; CUX1 gene Alternatively Spliced Product; GDDI; golgi integral membrane protein 6; GOLIM6; Homeobox protein cut-like 1; Homeobox protein cux-1; mutant CUX1; Nbla10317; p100; p110; p200; p75; protein CASP; putative protein product of Nbla10317

    For Research Use Only. Not for Use in Diagnostic Procedures.
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