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HPGDS (F2P9V) Rabbit Monoclonal Antibody

HPGDS (F2P9V) Rabbit Monoclonal Antibody #86637

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Product Specifications

REACTIVITY	H M
SENSITIVITY	Endogenous
MW (kDa)	23
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human
M-Mouse

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

HPGDS (F2P9V) Rabbit Monoclonal Antibody recognizes endogenous levels of total HPGDS protein.

Species Reactivity:

Human, Mouse

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human HPGDS protein.

Background

Hematopoietic prostaglandin D synthase (HPGDS) is a key enzyme in prostaglandin D2 (PGD2) biosynthesis. Studies show that Tuft-2 cells, a type of intestinal epithelial cell, sense bacterial metabolite N-undecanoylglycine (N-C11-G) and initiate PGD2 biosynthesis. PGD2 enhances the mucus secretion of goblet cells and, therefore, antibacterial immunity. HPGDS deletion in Tuft-2 cells leads to inadequate mucus secretion (1). In addition, HPGDS expression is downregulated in immunosuppressive tumor-associated macrophages (TAMs) in melanomas by TNFα released from activated T cells. This reduces PGD2 biosynthesis in TAMs and promotes an antitumoral tumor microenvironment (2). Furthermore, lipid metabolism was shown to be dysfunctional 15 years before the onset of Parkinson’s disease (PD), and plasma HPGDS levels continued to decline before PD diagnosis (3). HPGDS may play a role in PD pathogenesis (4).

Alternate Names

epididymis secretory sperm binding protein; Glutathione S-transferase; glutathione S-transferase sigma; Glutathione-dependent PGD synthase; glutathione-dependent PGD synthetase; Glutathione-requiring prostaglandin D synthase; GST class-sigma; GSTS; GSTS1; GSTS1-1; H-PGDS; Hematopoietic prostaglandin D synthase; hematopoietic prostaglandin D2 synthase; HPGDS; PGD2; PGDS; Prostaglandin-H2 D-isomerase; PTGDS2

Database Links

UniProt ID: O60760

Entrez-Gene Id: 27306

Limited Uses

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For Research Use Only. Not for Use in Diagnostic Procedures.

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