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  3. MUC2 (CCP58) Mouse Monoclonal Antibody
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MUC2 (CCP58) Mouse Monoclonal Antibody #88686

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  • IHC

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) >250
    Source/Isotype Mouse IgG1 kappa
    Application Key:
    • IHC-Immunohistochemistry 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    IHC Leica Bond 1:800 - 1:3200
    Immunohistochemistry (Paraffin) 1:800 - 1:3200

    Storage

    Supplied in 10 mM PBS containing 0.05% BSA and 0.05% sodium azide. Stable for 36 months when stored at -20°C. This product will freeze at -20°C so it is recommended to aliquot into single-use vials to avoid multiple freeze/thaw cycles. A slight precipitate may be present, but will not interfere with antibody performance.

    Protocol

    Specificity / Sensitivity

    MUC2 (CCP58) Mouse Monoclonal Antibody recognizes endogenous levels of total MUC2 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide from human MUC2 protein, coupled to KLH.

    Background

    Mucins are a family of large glycoproteins that create the structural component of mucus. Mucus functions as a blockade against pathogenic invasion and physical injury to the respiratory, gastrointestinal, and urogenital tracts (1). Mucins create a protective layer for epithelial cells as either membrane-bound (MUC1, MUC3, MUC16, and MUC17) or secreted (MUC2, MUC5AC, and MUC19) proteins. MUC2, or mucin-2, the main O-glycosylated protein found in mucus, is secreted by goblet cells (2). The structure of MUC2 contains cysteine-rich N- and C-terminal domains along with a protein core made up of heavily O-glycosylated mucin domains. The high levels of O-glycosylation along with disulfide bonding make MUC2 resistant to proteolytic cleavage (3). Mucin expression and glycan structure changes occur in cancers of the intestine and impact the development and progression of these cancers (4). The presence of MUC2 in the mucous layer of the colon helps prevent ulcerative colitis (UC) by inhibiting the invasion of bacteria (5).

    Alternate Names

    Intestinal mucin-2; MLP; MUC-2; MUC2; mucin 2, intestinal/tracheal; mucin 2, oligomeric mucus/gel-forming; Mucin-2; mucin-like protein; SMUC

    Database Links

    UniProt ID: Q02817


    Entrez-Gene Id: 4583


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