DNA Polymerase beta (F5I2R) Rabbit Monoclonal Antibody #89011
- WB
Product Specifications
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 40 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
DNA polymerase β expression levels and mutations are associated with human cancer (3-6). Inhibition or downregulation of DNA polymerase β is synthetic lethal with defective mismatch repair (MMR) in models of acute lymphoblastic leukemia (ALL) (7) and with BRCA1 deficiency in models of breast cancer (8).
- Gohil, D. et al. (2023) Int J Mol Sci 24, 14186. doi: 10.3390/ijms241814186.
- Horton, J.K. et al. (2022) DNA Repair (Amst) 116, 103357.
- Shahi, A. and Kidane, D. (2024) Clin Exp Med 24, 239.
- Al-Kawaz, A. et al. (2021) Breast Cancer Res Treat 190, 39-51.
- Qin, J. et al. (2021) Neoplasia 23, 663-675.
- Kladova, O.A. et al. (2022) Int J Mol Sci 23, 2390. doi: 10.3390/ijms23042390.
- Teng, J.Y. et al. (2023) Leukemia 37, 1204-1215.
- Yuhas, S.C. et al. (2021) ACS Chem Biol 16, 1339-1343.
Alternate Names
DNA pol beta; DNA polymerase beta; DNA polymerase beta subunit; DNA-directed DNA polymerase beta; DPOLB; MGC125976; POLB; polymerase (DNA directed), beta; polymerase (DNA) beta
Limited Uses
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