Lamellipodin (D8A2K) Rabbit Monoclonal Antibody #91138
- WB
- IF
Product Specifications
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 195 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IF-Immunofluorescence
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunofluorescence (Immunocytochemistry) | 1:200 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Lamellipodin (Lpd) is a member of the Mig-10/RIAM/lamellipodin (MRL) family of adaptor proteins. Lamellipodin regulates the formation of lamellipodia at the leading edge through its interaction with and recruitment of actin-modulating proteins such as Ena/VASP (3) and the Scar/WAVE complex (4). Lamellipodin and Mena cooperate with endophilin to regulate EGFR endocytosis (5). MRL proteins can also form complexes with talin and activated integrins, guiding the formation of cell protrusions and the direction of cell migration (6).
- Rottner, K. and Stradal, T.E. (2011) Curr Opin Cell Biol 23, 569-78.
- Wells, A. et al. (2013) Trends Pharmacol Sci 34, 283-9.
- Hansen, S.D. and Mullins, R.D. (2015) Elife 4, .
- Law, A.L. et al. (2013) J Cell Biol 203, 673-89.
- Vehlow, A. et al. (2013) EMBO J 32, 2722-34.
- Lagarrigue, F. et al. (2015) Nat Commun 6, 8492.
Alternate Names
ALS2CR18; ALS2CR9; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 18; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 9; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein; KIAA1681; Lamellipodin; LPD; PREL-2; PREL2; proline rich EVH1 ligand 2; Proline-rich EVH1 ligand 2; Protein RMO1; RalGDS/AF-6; RAPH1; Ras association (RalGDS/AF-6) and pleckstrin homology domains 1; Ras-associated and pleckstrin homology domains-containing protein 1; RMO1
Limited Uses
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