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6/12/2026, 10:17:52 AM UTC
Commit: a854f3e2d877b833e27badd637de63a8a4794b83
XML generation date: 2026-06-05 19:20:38.299
Product last modified at: 2026-06-06T07:01:28.203Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

CK2 beta (F1E2U) Rabbit Monoclonal Antibody #92888

Filter:
  • WB

    Product Specifications

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 25
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Simple Western™ 1:10 - 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    CK2 beta (F1E2U) Rabbit Monoclonal Antibody recognizes endogenous levels of total CK2 beta protein. Based on the protein sequence recognized by this antibody, it is not expected to cross-react with other casein kinase proteins. This antibody detects an approximately 15 kDa protein of unknown identity in some cell lines.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a recombinant protein specific to full-length human CK2 beta protein. This antibody recognizes residues surrounding Lys134 of human CK2 beta protein.

    Background

    CK2 (formerly called Casein Kinase II) is a highly conserved protein kinase with more than 300 substrates regulating cell growth, cell death, and cell survival. CK2 has been implicated in the response to UV irradiation-induced DNA damage, targeting XRCC1 (1) and BRCA1 (2) as well as regulating p53 tumor suppressor protein functions (3). Furthermore, CK2 plays a key role in NF-κB activation (4). UV irradiation stimulates CK2-mediated phosphorylation of several carboxy-terminal residues within IκBα, resulting in IκBα proteasomal degradation and the release and nuclear translocation of active NF-κB. CK2 is also dysregulated in many cancers (5) and neurodegenerative diseases such as Alzheimer's and Parkinson's diseases (6). Structurally, CK2 is a multimeric protein complex consisting of two catalytic subunits (α or α') and two regulatory β subunits (7). CK2 is distributed ubiquitously and is apparently constitutively active (7). While cell cycle-dependent Ser-Pro phosphorylation sites have been identified on CK2α and CK2β, Tyr255 phosphorylation by the Src-related kinase c-Fgr seems to have the greatest effect on CK2α activity (8,9).

    Alternate Names

    alternative name: G5a, phosvitin; casein kinase 2 beta; Casein kinase 2 beta polypeptide; Casein kinase 2, beta polypeptide; Casein kinase 2, beta polypeptide, isoform CRA_d; Casein kinase II beta subunit; Casein kinase II subunit beta; CK II beta; CK2B; CK2N; Ckb1; Ckb2; CSK2B; CSNK2B; CSNK2B-LY6G5B-1072; CSNK2B-LY6G5B-1103; CSNK2B-LY6G5B-532; CSNK2B-LY6G5B-560; CSNK2B-LY6G5B-562; G5A; MGC138222; MGC138224; phosvitin; POBINDS; protein G5a

    For Research Use Only. Not for Use in Diagnostic Procedures.
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