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  3. AP3B1 (E7U2P) Rabbit Monoclonal Antibody
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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

AP3B1 (E7U2P) Rabbit Monoclonal Antibody #95765

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  • WB
  • IP

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 135
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    AP3B1 (E7U2P) Rabbit Monoclonal Antibody recognizes endogenous levels of total AP3B1 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human AP3B1 protein.

    Background

    The adaptor protein complex 3 (AP-3) is a ubiquitously expressed, heterotetramer that is comprised of two large adaptins (AP3D1 and either AP3B1 or AP3B2), a medium adaptin (AP3M1 or AP3M2), and a small adaptin (AP3S1 or AP3S2). The AP-3 complex is involved in the sorting of protein cargo within the endosomal compartment that are destined for lysosomes (1,2). Defects in the AP-3 complex have been associated with Hermansky-Pudlak syndrome (HPS), a genetic disorder characterized by abnormal skin pigmentation, blood clotting abnormalities, and pulmonary fibrosis. Mutations in the gene encoding ubiquitously expressed AP3B1/β3A, destabilize the protein and the entire AP-3 complex, which results in defective trafficking of lysosomal membrane proteins (3,4). Research studies have shown that certain viral proteins have evolved to co-opt the AP-3 complex by binding to AP3B1 in order to facilitate viral particle assembly (5).

    Alternate Names

    Adapter-related protein complex 3 subunit beta-1; Adaptor protein complex AP-3 subunit beta-1; adaptor related protein complex 3 beta 1 subunit; adaptor related protein complex 3 subunit beta 1; Adaptor-related protein complex 3 subunit beta-1; adaptor-related protein complex 3, beta 1 subunit; ADTB3; ADTB3A; AP-3 complex beta-3A subunit; AP-3 complex subunit beta-1; AP3B1; Beta-3A-adaptin; beta3A-adaptin; Clathrin assembly protein complex 3 beta-1 large chain; HPS; HPS2; PE

    Database Links

    UniProt ID: O00203


    Entrez-Gene Id: 8546


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    For Research Use Only. Not for Use in Diagnostic Procedures.
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