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  3. MXRA7 (F7P7E) Rabbit Monoclonal Antibody
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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

MXRA7 (F7P7E) Rabbit Monoclonal Antibody #96582

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    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 35-45
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    • IHC-Immunohistochemistry 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50
    Immunohistochemistry (Paraffin) 1:250 - 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    MXRA7 (F7P7E) Rabbit Monoclonal Antibody recognizes endogenous levels of total MXRA7 protein. This antibody detects a nonspecific band at 85 kDa in some cell lines.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MXRA7 protein.

    Background

    Tumor cells possess a notorious ability to change the extracellular matrix (ECM). This hijacking of ECM infrastructure enables tumor cells to manipulate the tumor microenvironment (TME), allowing cancer growth and metastasis (1,2). The interactions between tumor cells, the ECM, and other cells, including immune cells and fibroblasts, coordinate signaling that can drive tumor progression and affect response to therapies (3). A transcriptional co-expression analysis across human cDNA libraries identified a gene family called Matrix remodeling associated genes (MXRAs) (4). Several MXRAs have been shown to coordinate biological processes, such as cell adhesion, matrix remodeling, angiogenesis, and inflammation (3,4). Interestingly, there is no structural homology between MXRA family members (4). MXRA7 was originally shown to be highly expressed in leukemias (5) and some solid tumor types (6). MXRA7 can enhance the expression of matrix remodeling-related genes (3-6). MXRA7 also has a role in immune cell biology and inflammation. Studies using siRNA knockdown or transgenic MXRA7 knockout mice demonstrate that MXRA7 is involved in megakaryocyte differentiation and platelet production (7). Furthermore, MXRA7 facilitates monocyte-to-macrophage differentiation, likely through the NF-kappaB signaling pathway (8). The precise structure and functional significance of MXRA7 is still not completely understood, and more investigation is necessary, particularly in the context of tumor biology, immune response, and potential cancer therapies.

    Alternate Names

    FLJ41492; FLJ46603; HBV PreS1-transactivated protein 1; matrix remodeling associated 7; Matrix-remodeling-associated protein 7; matrix-remodelling associated 7; MXRA7; PS1TP1; TMAP1; Transmembrane anchor protein 1

    Database Links

    UniProt ID: P84157


    Entrez-Gene Id: 439921


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    For Research Use Only. Not for Use in Diagnostic Procedures.
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