SARS-CoV-2 Nsp2 (E3Q9Z) Rabbit Monoclonal Antibody #96795
- WB
Product Specifications
| REACTIVITY | Vir |
| SENSITIVITY | Endogenous |
| MW (kDa) | 80 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- Vir-Virus
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Nsp2 (non-structural protein 2) is derived from ORF1a and ORF1b (2). It is reported to interact with a protein involved in translational repression known as GIGYF2. GIGYF2 normally interacts with another translational repressor, 4EHP. These proteins together in a larger complex function to inhibit translation of mRNAs that may be defective during development. Upon infection with SARS-CoV-2, however, Nsp2 binds to GIGYF2 and exerts a stronger effect on host cell translation by 4EHP dependent and independent mechanisms, with inhibition of interferon translation being one of the notable effects (3).
Alternate Names
non-structural protein 2; non-structural protein 2 (181-818); nsp2; nsp2-pp1a-pp1ab; p65 homolog; SARS-CoV-2 nsp2
Limited Uses
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