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MSR1 (E7P6W) Rabbit Monoclonal Antibody #98215

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  • IHC

    Product Specifications

    REACTIVITY M
    SENSITIVITY Endogenous
    MW (kDa)
    Source/Isotype Rabbit IgG
    Application Key:
    • IHC-Immunohistochemistry 
    Species Cross-Reactivity Key:
    • M-Mouse 

    Product Information

    Product Usage Information

    Application Dilution
    Immunohistochemistry (Paraffin) 1:150 - 1:600

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    MSR1 (E7P6W) Rabbit Monoclonal Antibody recognizes endogenous levels of total MSR1 protein. Non-specific staining was observed in mouse testis and pancreatic islets by immunohistochemistry.

    Species Reactivity:

    Mouse

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of mouse MSR1 protein.

    Background

    Macrophage Scavenger receptor types I and II (MSR1, also known as SCARA1) are members of the class A macrophage scavenger receptor family. These proteins bind large quantities of modified lipoproteins and promote endocytosis. Upregulation of MSR1 in infiltrating myeloid cells may mediate clearance of specific damage signals in response to tissue injury, including ischemic stroke (1). MSR1 germline mutations are also associated with increased prostate cancer susceptibility in some patient cohorts (2). MSR1 is observed to be upregulated in differentiated THP-1 cells (3).

    Alternate Names

    CD204; Macrophage acetylated LDL receptor I and II; macrophage scavenger receptor 1; Macrophage scavenger receptor types I and II; MRS-A; MSR; MSR-A; Msr1; MSRE; Scara1; Scavenger receptor type A; Scvr; SR-A; SR-AI; SR-AII

    For Research Use Only. Not for Use in Diagnostic Procedures.
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