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Render Timestamp:
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5/20/2026, 10:17:12 AM UTC
Commit: 7ed46ecc04b401f23a28df741b5078df405d23e4
XML generation date: 2026-05-11 23:50:34.545
Product last modified at: 2026-03-20T08:00:23.668Z
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PDP - Template Name: Antibody Sampler Kit
PDP - Template ID: *******4a3ef3a

MAPK Family Antibody Sampler Kit #9926

    Product Information

    Product Description

    The MAPK Family Antibody Sampler Kit provides an economical means of evaluating total levels of p38, p44/42, and SAPK/JNK mitogen-activated protein kinases. The kit contains enough primary and secondary antibody to perform two western blot experiments.

    Background

    p44/42 MAPK (Erk1/2), SAPK/JNK, and p38 MAPK function in protein kinase cascades that play a critical role in the regulation of cell growth, differentiation, and control of cellular responses to cytokines and stress. p44/42 MAPK is activated by growth and neurotrophic factors. Activation occurs through phosphorylation of threonine and tyrosine residues (Thr202 and Tyr204 in human Erk1) at the sequence T*EY* by a single upstream MAP kinase kinase (MEK). SAPK/JNK and p38 MAPK are activated by inflammatory cytokines and by a wide variety of cellular stresses. Activation of SAPK/JNK occurs via phosphorylation at Thr183 and Tyr185 by the dual specificity enzyme SEK/MKK4. Both MKK3 and SEK phosphorylate p38 MAPK on tyrosine and threonine at the sequence T*GY* to activate p38 MAP kinase (1-5).

    Alternate Names

    Erk1; Erk1/2; Erk2; JNK; p38; p42; p44; p44/42; SAPK

    For Research Use Only. Not for Use in Diagnostic Procedures.
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