Name: Cadherin-Catenin Antibody Sampler Kit
Price: 581.00 USD
Availability: InStock

Product Information

Product Description

This Cadherin-Catenin Antibody Sampler kit contains reagents to examine the total protein levels of key proteins found in cell-cell adherens junctions. The kit contains enough primary and secondary antibodies to perform two Western blot experiments.

Background

Adherens junctions are dynamic structures that form cell-cell contacts and are important in development, differentiation, tissue integrity, morphology and cell polarity. They are composed of cadherins that are transmembrane proteins that bind cadherins on adjacent cells in a calcium dependent manner. On the cytoplasmic side of adherens junctions, the cadherins associate with β-catenin, γ-catenin and p120 catenin (δ). β-catenin and γ-catenin associate with α-catenin, which links the cadherin-catenin complex to the actin cytoskeleton (1,2). Recent studies indicate that cancer cells exhibit increased N-cadherin and diminished E-cadherin expression. E-cadherin is considered a suppressor of invasive cancer cell growth and this change in cadherin expression associated with cancer progression is termed the “cadherin switch”. β-catenin is one of the key downstream effectors in the Wnt signaling pathway and has been implicated in early embryonic development and tumorigenesis (3-5).

Alternate Names

CAD; cadherin; catenin; CTN; CTNB1; CTNNB; CTNNB1; cytoskeletal-signaling; e-cadherin; ecadherin; α-E-Catenin; α-ECatenin; αE-Catenin; αECatenin; β-Catenin; βCatenin

Database Links

UniProt ID: P19022 , P22223 , P12830 , P35222 , P55283 , P35221

Entrez-Gene Id: 1000 , 1001 , 999 , 1499 , 1002 , 1495

Limited Uses

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For Research Use Only. Not for Use in Diagnostic Procedures.

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Cadherin-Catenin Antibody Sampler Kit #9961