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ABT-263 (Navitoclax)
Activators & Inhibitors
Chemical Modulators

ABT-263 (Navitoclax) #79381

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ABT-263 (Navitoclax): Image 1
Western blot analysis of extracts from HeLa cells, untreated (-) or treated with ABT-263 (Navitoclax) (10 μM, 24 hr; +), using Cleaved Caspase-9 (Asp315) (D8I9E) Rabbit mAb #20750 (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower).
ABT-263 (Navitoclax): Image 2
Chemical structure of ABT-263 (Navitoclax).

Product Usage Information

ABT-263 (Navitoclax) is supplied as a lyophilized powder. For a 5 mM stock, reconstitute 5 mg of powder in 1.0 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.


Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight 974.6 g/mol
Purity >98%
Molecular Formula C47H55CIF3N5O6S3
CAS 923564-51-6
Solubility Soluble in DMSO at 25 mg/ml.


ABT-263 (Navitoclax) is a potent and orally bioavailable Bcl-2 family inhibitor. This small molecule mimetic of BH3 domains specifically binds to Bcl-2, Bcl-xL, and Bcl-W with a Ki value of less than 1 nM (1). ABT-263 (Navitoclax) has been shown to have antitumor effects on small cell lung cancer (SCLC) xenograft models, resulting in complete tumor regression in some cases (2). Studies have shown that ABT-263 (Navitoclax) can enhance the effectiveness of chemotherapeutic and targeted agents against solid tumors (3). ABT-263 (Navitoclax) induces apoptosis, particularly in certain types of senescent cells (4,5).
  1. Tse, C. et al. (2008) Cancer Res 68, 3421-8.
  2. Shoemaker, A.R. et al. (2008) Clin Cancer Res 14, 3268-77.
  3. Chen, J. et al. (2011) Mol Cancer Ther 10, 2340-9.
  4. Zhu, Y. et al. (2016) Aging Cell 15, 428-35.
  5. Zhu, Y. et al. (2015) Aging Cell 14, 644-58.

Limited Uses

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Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

For Research Use Only. Not For Use In Diagnostic Procedures.
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To Purchase # 79381
Cat. # Size Qty. Price
5 mg
$ 165