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57583
AdipoRon
Activators & Inhibitors
Chemical Modulators

AdipoRon #57583

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AdipoRon: Image 1
Chemical structure of AdipoRon.

Product Usage Information

AdipoRon is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.17 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at room temperature, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 2 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight 428.5 g/mol
Purity >98%
Molecular Formula C27H28N2O3
CAS 924416-43-3
Solubility Soluble in DMSO at 40 mg/mL or ethanol at 20 mg/mL.

Background

AdipoRon is a small, synthetic molecule that binds both adiponectin receptors AdipoR1 and AdipoR2 with a Kd of approximately 1.8 and 3.1 mM, respectively. This synthetic adiponectin receptor agonist exhibits strong anti-obesity, anti-diabetic, anti-depressant, anti-ischemic, and anti-hypertrophic activities (1). AdipoRon behaves similarly to adiponectin in muscle and liver tissues of mice that are fed a high-fat diet, reducing insulin resistance and glucose intolerance through activation of the AMPK and PPAR-α pathways (2). Clinically, AdipoRon can be used to improve post-traumatic stress disorder, anxiety, and systemic sclerosis; it is being evaluated for the treatment of several forms of cancer, including pancreatic ductal adenocarcinoma, myeloma, breast, and ovarian cancer (3). Treatment of myeloma cell lines with AdipoRon significantly induced expression of the apoptosis-related proteins cleaved caspase-3 and cleaved PARP, and inhibited cell proliferation (4). A study using a mouse model of hypertension indicated that this AdipoRon treatment could prevent renal fibrosis in hypertensive patients (5).
  1. Bhat, I.A. et al. (2020) Curr Mol Pharmacol 13, 94-107.
  2. Okada-Iwabu, M. et al. (2013) Nature 503, 493-9.
  3. Nigro, E. et al. (2021) Int J Mol Sci 22, 5569. doi: 10.3390/ijms22115569.
  4. Wang, S.J. et al. (2020) Zhongguo Shi Yan Xue Ye Xue Za Zhi 28, 171-176.
  5. Li, Y. et al. (2021) J Cardiovasc Transl Res 14, 538-545.

Limited Uses

Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

For Research Use Only. Not For Use In Diagnostic Procedures.
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To Purchase # 57583
Cat. # Size Qty. Price
57583S
5 mg
$ 53