Bisindolylmaleimide I (GF-109203X) #37969
Product Information
Product Usage Information
Storage
Product Description
| Molecular Weight | 412.5 g/mol |
| Purity | >98% |
| Molecular Formula | C25H24N4O2 |
| CAS | 133052-90-1 |
| Solubility | Soluble in DMSO at 10 mg/mL or DMF at 10 mg/mL. |
Background
Bisindolylmaleimide I (BIS), also known as GF-109203X, is a potent inhibitor of PKC (1,2). In vitro, the IC50 of BIS is 10-20 nM for PKCα/β/γ and 100-200 nM for PKCδ/ε isoforms. The in vitro IC50 for PKCζ is approximately 6 μM, indicating that BIS is a very weak inhibitor for this isoform. In in vivo cellular assays, the IC50 of BIS for PKC is 0.2-2 μM (1,3).
Limited Uses
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