BMS-303141 #89022

Name: BMS-303141
Price: 109.00 USD
Availability: InStock

Product Information

Product Usage Information

BMS-303141 is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 0.79 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight	424.3 g/mol
Purity	>98%
Molecular Formula	C₁₉H₁₅Cl₂NO₄S
CAS	943962-47-8
Solubility	Soluble in DMSO at 25 mg/mL or ethanol at 20 mg/mL.

Background

The small-molecule BMS-303141 is a potent (IC₅₀= 0.13 μM) inhibitor of ATP-citrate lyase (ACL). ACL catalyzes the formation of cytosolic acetyl-CoA and oxaloacetate (OAA) in the cytosol, which is the key step for fatty acid and cholesterol biosynthesis. BMS-303141 also weakly inhibits acetyl-CoA carboxylase (ACC) isoforms ACC1 and ACC2. Treatment of high-fat fed mice with BMS-303141 reduced weight gain and decreased levels of plasma cholesterol, triglycerides, and glucose (1). BMS-303141 treatment of prostate cancer cells impaired cell proliferation or induced death in androgen-depleted, castration-resistant prostate cancer cells (2). Hepatocellular carcinoma cells responded to treatment with BMS-303141, reducing cell proliferation and promoting apoptosis. BMS-303141 is thought to induce endoplasmic reticulum (ER) stress and activate the p-eIF2α/ATF4/CHOP pathway to promote apoptosis. The combined treatment of a mouse xenograft model with BMS-303141 and a protein kinase inhibitor reduced tumor volume and weight (3).

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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