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Camostat Mesylate
Activators & Inhibitors
Chemical Modulators

Camostat Mesylate #42819

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Chemical structure of Camostat Mesylate.

Product Usage Information

Camostat Mesylate is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 10 mg of powder in 1.34 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.


Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight: 494.5 g/mol

Purity: >98%

Molecular Formula: C20H22N4O5 • CH3SO3H

CAS: 59721-29-8

Solubility: Soluble in DMSO at 50 mg/ml or water at 50 mg/ml.


Camostat Mesylate, also known as Foipan or FOY 305, is a synthetic serine protease inhibitor that is often used to treat pancreatitis pain (1). Camostat Mesylate attenuates airway epithelial sodium channel (ENaC) function by inhibiting channel-activating proteases (CAPs) with an IC50 of 50 nM (2). Camostat Mesylate inhibition of trypsin decreased food intake, body weight, blood glucose, liver weight, and lipidosis and increased FGF21 expression in obese mice (3).

Camostat Mesylate is an effective inhibitor of TMPRSS2, a serine protease used by SARS-CoV-2/COVID-19 for viral S-protein priming and cell entry. Pre-treatment of human lung cancer cells with 100 μM Camostat Mesylate significantly reduced COVID-19 viral entry (4).

  1. Ramsey, M.L. et al. (2019) Trials 20, 501.
  2. Coote, K. et al. (2009) J Pharmacol Exp Ther 329, 764-74.
  3. Albarazanji, K. et al. (2019) Am J Physiol Gastrointest Liver Physiol 316, G653-G667.
  4. Hoffmann, M. et al. (2020) Cell 181, 271-280.e8.
For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

To Purchase # 42819S
Product # Size Price
10 mg $ 59