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Concanamycin A
Activators & Inhibitors
Chemical Modulators

Concanamycin A #29442

Citations (0)
Chemical structure of Concanamycin A.

Product Usage Information

Concanamycin A is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 10 μg of powder in 1.15 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.


Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight 866.1 g/mol
Purity >98%
Molecular Formula C46H75NO14
CAS 80890-47-7
Solubility Soluble in DMSO at 50 mg/mL.


Concanamycin A is a macrolide antibiotic derived from S. diastatochromogenes that is effective against several fungi and yeasts (1). Concanamycin A is an exceptionally potent and specific inhibitor of the ATP-driven proton pumps known as vacuolar type H+-ATPases (V-ATPases). V-ATPases acidify intracellular compartments and translocate protons across the plasma membrane. Intracellular V-ATPases play an important role in endocytosis and intracellular membrane trafficking, while plasma membrane V-ATPases are important in processes such as urinary acidification and bone resorption (2). Treatment of murine cells with Concanamycin A results in apoptosis, evidenced by an increase in fragmented DNA and the number of apoptotic cells with hypodiploid DNA (3). Concanamycin A induced production of nitric oxide and decreased cell growth and survival in mouse leukemic monocyte cells (4). Concanamycin A reversed the downregulation of cell surface MHC-I by the HIV-encoded accessory protein Nef, suggesting a possible therapeutic role of Concanamycin A in enhancing the immune-mediated clearance of HIV-infected cells (5).

Limited Uses

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For Research Use Only. Not for Use in Diagnostic Procedures.
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To Purchase # 29442
Cat. # Size Qty. Price
20 µg