Cytochalasin D #94946

Name: Cytochalasin D
Price: 180.00 USD
Availability: InStock

Product Information

Product Usage Information

Cytochalasin D is supplied as a lyophilized powder. For a 5 mM stock, reconstitute 1 mg of powder in 0.39 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight	507.6 g/mol
Purity	>98%
Molecular Formula	C₃₀H₃₇NO₆
CAS	22144-77-0
Solubility	Soluble in DMSO at 20 mg/mL or ethanol at 5 mg/mL.

Background

The fungal-derived toxin Cytochalasin D is a potent inhibitor of actin polymerization, limiting elongation at both the barbed and pointed ends of the actin filament (1). While several related Cytochalasin toxins bind actin and alter polymerization, Cytochalasin D is the most specific inhibitor of actin microfilaments (2). The cytoskeleton takes part in signal transduction, protein transport, signal compartmentalization, and cell mobility. Depolymerization of the actin cytoskeleton by Cytochalasin D in mesenchymal stem cells results in localization of G-actin to the nucleus, which leads to mesenchymal stem cell differentiation and bone formation (3). Treatment of a pair of cancer cell lines with Cytochalasin D results in the inhibition of actin polymerization and decreased cell motility (4). Treatment of murine CT26 colorectal carcinoma cells with Cytochalasin D inhibited tumor growth through reduced cell proliferation, induction of cell apoptosis, and suppression of tumor angiogenesis (5).

Alternate Names

(7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10- phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione

Limited Uses

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For Research Use Only. Not for Use in Diagnostic Procedures.

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