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Docetaxel #9886
Western blot analysis of extracts from HT-29 cells treated with Docetaxel (100 ng/ml) for the indicated times using Cyclin B1 Antibody #4138 (upper) or Phospho-Aurora A (Thr288) (C39D8) Rabbit mAb #3079 (lower).
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Structure of Docetaxel
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Product Usage Information
Docetaxel is supplied as 1 mg powder. Store at or below -20ºC. Before use, dissolve powder in 1 ml DMSO to make a 1 mg/ml stock solution. The suggested working concentration is 100 ng/ml in tissue culture medium. Treat cells for 4-24 hours. Store solution at -20ºC.
Storage: Store lyophilized or in solution at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.Product Description
Molecular Weight:
807.89 g/mol
Purity:>99%
Molecular Formula:C43H53NO14
Background
Docetaxel belongs to the taxane family of antitumor and antileukemic agents (1). A microtubule-stabilizing agent, docetaxel acts as an inhibitor of cellular functions that require microtubule dynamics including cell division, and is now in use as a treatment for breast, prostate and lung cancer (2).
1. Abal, M. et al. (2003) Curr Cancer Drug Targets 3, 193-203.
Data Sheets & Documentation
For Research Use Only. Not For Use In Diagnostic Procedures. Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
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