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60887
Dorsomorphin (Compound C)
Activators & Inhibitors
Chemical Modulators

Dorsomorphin (Compound C) #60887

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Dorsomorphin (Compound C): Image 1

Western blot analysis of extracts from C2C12 cells, untreated (-) or treated with combinations of the following treatments as indicated: AICAR #9944 (2 mM, 24 hr; +) and Dorsomorphin (Compound C) (10 μM, 24 hr; +), using Phospho-AMPKα (Thr172) (40H9) Rabbit mAb #2535 (upper), AMPKα Antibody #2532 (middle), or β-Actin (D6A8) Rabbit mAb #8457 (lower).

Dorsomorphin (Compound C): Image 2

Chemical structure of Dorsomorphin (Compound C).

Product Usage Information

Dorsomorphin (Compound C) is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.25 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight 399.5 g/mol
Purity

>98%

Molecular Formula

C24H25N5O

CAS 866405-64-3
Solubility Soluble in DMSO at 4 mg/ml with warming.

Background

Dorsomorphin (Compound C) is a potent and reversible AMP-activated protein kinase (AMPK) inhibitor that competes with ATP in the absence of AMP with a Ki value of 109 nM (1). This small compound is selective, displaying no significant inhibition of other kinases inclusive of ZAPK, SYK, PKCθ, PKA, and JAK3 (1). Research has shown that Dorsomorphin (Compound C) inhibits tumor cell proliferation and induces apoptosis through mechanisms independent of the AMPK pathway (2). This compound inhibits the effects that AICAR and metformin have on inactivating acetyl-CoA carboxylase (ACC) and selectively inhibits the BMP type I receptors ALK2, ALK3, and ALK6 (1,3). 

  1. Zhou, G. et al. (2001) J Clin Invest 108, 1167-74.
  2. Liu, X. et al. (2014) Mol Cancer Ther 13, 596-605.
  3. Yu, P.B. et al. (2008) Nat Chem Biol 4, 33-41.

Limited Uses

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Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST's products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST's Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
To Purchase # 60887S
Product # Size Price
60887S
5 mg $ 91

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