Entacapone #96692
Product Information
Product Usage Information
Entacapone is supplied as a lyophilized powder. For a 30 mM stock, reconstitute 10 mg of powder in 1.09 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Storage
Product Description
| Molecular Weight | 305.3 g/mol |
| Purity | >98% |
| Molecular Formula | C14H15N3O5 |
| CAS | 130929-57-6 |
| Solubility | Soluble in DMSO at 30 mg/ml or ethanol at 3 mg/ml. |
Background
Entacapone, also known as OR-611, is a catechol O-methyltransferase (COMT) inhibitor with IC50 values ranging from 10 nM to 160 nM for rat duodenum and rat liver COMT, respectively (1,2). Taken as an adjuvant with levodopa/carbidopa therapy, entacapone blocks COMT methylation and subsequent degradation of plasma levodopa, prolonging and improving therapeutic response in Parkinson’s patients (3,4). Entacapone inhibition of COMT also works synergistically with (-)-Epigallocatechin-3-gallate (EGCG) to inhibit human and murine lung cancer cell growth in vitro (5).
- Männistö, P.T. et al. (1992) Br J Pharmacol 105, 569-74.
- Nissinen, E. et al. (1992) Naunyn Schmiedebergs Arch Pharmacol 346, 262-6.
- Najib, J. (2001) Clin Ther 23, 802-32; discussion 771.
- Trenkwalder, C. et al. (2019) Neurology 92, e1487-e1496.
- Forester, S.C. and Lambert, J.D. (2014) Carcinogenesis 35, 365-72.
Limited Uses
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