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Activators & Inhibitors
Chemical Modulators

Entacapone #96692

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Chemical structure of Entacapone.

Product Usage Information

Entacapone is supplied as a lyophilized powder. For a 30 mM stock, reconstitute 10 mg of powder in 1.09 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.


Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight: 305.3 g/mol

Purity: >98%

Molecular Formula: C14H15N3O5

CAS: 130929-57-6

Solubility: Soluble in DMSO at 30 mg/ml or ethanol at 3 mg/ml.


Entacapone, also known as OR-611, is a catechol O-methyltransferase (COMT) inhibitor with IC50 values ranging from 10 nM to 160 nM for rat duodenum and rat liver COMT, respectively (1,2). Taken as an adjuvant with levodopa/carbidopa therapy, entacapone blocks COMT methylation and subsequent degradation of plasma levodopa, prolonging and improving therapeutic response in Parkinson’s patients (3,4). Entacapone inhibition of COMT also works synergistically with (-)-Epigallocatechin-3-gallate (EGCG) to inhibit human and murine lung cancer cell growth in vitro (5).

  1. Männistö, P.T. et al. (1992) Br J Pharmacol 105, 569-74.
  2. Nissinen, E. et al. (1992) Naunyn Schmiedebergs Arch Pharmacol 346, 262-6.
  3. Najib, J. (2001) Clin Ther 23, 802-32; discussion 771.
  4. Trenkwalder, C. et al. (2019) Neurology 92, e1487-e1496.
  5. Forester, S.C. and Lambert, J.D. (2014) Carcinogenesis 35, 365-72.
For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

To Purchase # 96692S
Product # Size Price
10 mg $ 61