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Activators & Inhibitors
Chemical Modulators

Ferrostatin-1 #19766

Citations (0)
Chemical structure of Ferrostatin-1.

Product Usage Information

Ferrostatin-1 is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.27 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.


Store lyophilized at ambient temperature, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight 262.4 g/mol
Purity >98%
Molecular Formula C15H22N2O2
CAS 347174-05-4
Solubility Soluble in DMSO at 100 mg/mL or ethanol at 100 mg/mL.


Ferrostatin-1 is an antioxidant that is a potent, selective inhibitor of erastin-induced ferroptosis with an EC50 value of 60 nM (1,2). It effectively inhibits ferroptosis in cancer cells and prevents glutamate-induced cell death in rat hippocampal brain slices. In disease models, it has been shown to inhibit production of reactive oxygen species (ROS) and depletion of membrane lipids (1). Ferrostatin-1 has been shown to inhibit cell death in cell models of Huntington’s disease, periventricular leukomalacia, and kidney dysfunction (1,2).

Limited Uses

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Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

For Research Use Only. Not for Use in Diagnostic Procedures.
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To Purchase # 19766
Cat. # Size Qty. Price
5 mg