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83346
KU-55933
Activators & Inhibitors
Chemical Modulators
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KU-55933 #83346

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KU-55933: Image 1
Western blot analysis of extracts from HCT 116 cells, untreated (-) or treated with Doxorubicin #5927 (0.5 μM, 24 hr; +), either with or without KU-55933 pretreatment (10 μM, 1 hr; +), using Phospho-Chk2 (Thr68) (C13C1) Rabbit mAb #2197 (upper), Chk2 (D9C6) XP® Rabbit mAb #6334 (middle), and β-Actin (D6A8) Rabbit mAb #8457 (lower).
KU-55933: Image 2
Chemical structure of KU-55933.
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Product Usage Information

KU-55933 is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.26 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

MW (kDa) 395.5 g/mol
Purity >98%
Molecular Formula C21H17NO3S2
CAS 587871-26-9
Solubility Soluble in DMSO at 40 mg/ml or ethanol at 20 mg/ml.

Background

KU-55933 is a potent and selective ATP-competitive inhibitor of ATM kinase (IC50 = 13 nM and Ki = 2.2 nM). This small molecule has been shown to sensitize cancer cells to ionizing radiation and chemotherapeutic agents (1). Treating senescent cancer cells (MCF7, A549, and HCT 116) with KU-55933 results in decreased viability and cell death (2). KU-55933 has neuroprotective capabilities by preventing damage caused by oxidative stress (3).
  1. Hickson, I. et al. (2004) Cancer Res 64, 9152-9.
  2. Crescenzi, E. et al. (2008) Clin Cancer Res 14, 1877-87.
  3. Chwastek, J. et al. (2017) Int J Biochem Cell Biol 87, 38-53.

Limited Uses

Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST's products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST's Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

For Research Use Only. Not For Use In Diagnostic Procedures.
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To Purchase # 83346S
Product # Size Price
83346S		 5 mg $ 92

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